{"id":40780,"date":"2025-04-30T09:35:16","date_gmt":"2025-04-29T23:35:16","guid":{"rendered":"https:\/\/www.bitemagazine.com.au\/?p=40780"},"modified":"2025-04-30T09:35:20","modified_gmt":"2025-04-29T23:35:20","slug":"new-drug-therapy-with-natural-compound-shows-promise-against-periodontal-diseases","status":"publish","type":"post","link":"https:\/\/www.bitemagazine.com.au\/new-drug-therapy-with-natural-compound-shows-promise-against-periodontal-diseases\/","title":{"rendered":"New drug therapy with natural compound shows promise against periodontal diseases"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1.jpg\" alt=\"senescent cells periodontal disease\" class=\"wp-image-40781 lazyload\" data-srcset=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1.jpg 1024w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-300x200.jpg 300w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-768x512.jpg 768w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-630x420.jpg 630w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-150x100.jpg 150w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-600x400.jpg 600w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-696x464.jpg 696w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><noscript><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1.jpg\" alt=\"senescent cells periodontal disease\" class=\"wp-image-40781 lazyload\" srcset=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1.jpg 1024w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-300x200.jpg 300w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-768x512.jpg 768w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-630x420.jpg 630w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-150x100.jpg 150w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-600x400.jpg 600w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/04\/research-1-696x464.jpg 696w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><figcaption class=\"wp-element-caption\">Photo: armmypicca 123rf<\/figcaption><\/figure>\n\n\n\n<p>US researchers discovered in\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38877743\/\" target=\"_blank\" rel=\"noreferrer noopener\">a previous clinical study<\/a>\u00a0that the chronic gum inflammation can promote an ageing-related condition called \u2018senescence\u2019, even in younger tissues.\u00a0<\/p>\n\n\n\n<p>Senescent cells, which have permanently ceased to divide in response to stress, secrete inflammatory molecules that increase tissue damage, impair healing, and accelerate disease severity.<\/p>\n\n\n\n<p>Now, a new translational study by the same research team at Penn Dental Medicine reveals that targeting senescent cell burden could be an effective strategy for managing periodontal disease and promoting oral health.<\/p><div class=\"bitem-article-desktop-720x300-in-text\" id=\"bitem-267852242\"><!-- Bite 720x300 [async] -->\r\n<script type=\"text\/javascript\">if (!window.AdButler){(function(){var s = document.createElement(\"script\"); s.async = true; s.type = \"text\/javascript\";s.src = 'https:\/\/servedby.engagemedia.com.au\/app.js';var n = document.getElementsByTagName(\"script\")[0]; n.parentNode.insertBefore(s, n);}());}<\/script>\r\n<script type=\"text\/javascript\">\r\nvar AdButler = AdButler || {}; AdButler.ads = AdButler.ads || [];\r\nvar abkw = window.abkw || '';\r\nvar plc705185 = window.plc705185 || 0;\r\ndocument.write('<'+'div id=\"placement_705185_'+plc705185+'\"><\\\/'+'div>');\r\nAdButler.ads.push({handler: function(opt){ AdButler.register(165450, 705185, [720,300], 'placement_705185_'+opt.place, opt); }, opt: { place: plc705185++, keywords: abkw, domain: 'servedby.engagemedia.com.au', click:'CLICK_MACRO_PLACEHOLDER' }});\r\n<\/script><\/div>\n\n\n\n<p>In a paper published in the\u00a0<em><a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/00220345241299789\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Dental Research<\/a>,<\/em>\u00a0the researchers showed that an anti-senescence therapy or \u2018senotherapy\u2019, consisting of an enzyme inhibitor called dasatinib and a natural flavonoid plant compound called quercetin, reduced markers of senescence and associated periodontal inflammation and bone loss in lab-dish and animal models.<\/p>\n\n\n\n<p>Senotherapies, which target senescent cells by eliminating them or suppressing their harmful effects, are gaining attention for a host of potential clinical applications, and now periodontal diseases as well.<\/p>\n\n\n\n<p>In their new study, the team used the dasatinib-quercetin (DQ) combination, a senotherapy that has shown an ability to reduce senescent cell numbers and senescence markers in other clinical contexts.<\/p>\n\n\n\n<p>In lab-dish experiments, the team exposed gum cells called keratinocytes to periodontitis-associated bacteria, which induced a senescence-like molecular signature. Treatment with DQ significantly weakened this signature\u2014as did quercetin alone comparably.<\/p>\n\n\n\n<p>The results extended to a live animal model as well. In aging mice, which exhibit features of senescence as they age, DQ treatment significantly decreased senescence markers and senescence-associated inflammatory mediators in gum tissues, restoring them to levels observed in young, non-senescent gums. Importantly, the DQ supplements also prevented much of the loss of alveolar bone, suggesting that senotherapy could help preserve the structural integrity of the periodontium.<\/p>\n\n\n\n<p>\u201cThese results are consistent with our previous studies and a growing body of research that shows the powerful role of natural compounds, like quercetin, in promoting oral and systemic health,\u201d Dr Esra Sahingur said.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>US researchers discovered in\u00a0a previous clinical study\u00a0that the chronic gum inflammation can promote an ageing-related condition called \u2018senescence\u2019, even in younger tissues.\u00a0 Senescent cells, which have permanently ceased to divide in response to stress, secrete inflammatory molecules that increase tissue damage, impair healing, and accelerate disease severity. Now, a new translational study by the same [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":40781,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[8],"tags":[91,25703],"class_list":{"0":"post-40780","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-dental_news","8":"tag-periodontal-disease","9":"tag-senescent-cells"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.9 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New drug therapy with natural compound shows promise against periodontal diseases - Bite Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bitemagazine.com.au\/new-drug-therapy-with-natural-compound-shows-promise-against-periodontal-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New drug therapy with natural compound shows promise against periodontal diseases\" \/>\n<meta property=\"og:description\" content=\"US researchers discovered in\u00a0a previous clinical study\u00a0that the chronic gum inflammation can promote an ageing-related condition called \u2018senescence\u2019, even in younger tissues.\u00a0 Senescent cells, which have permanently ceased to divide in response to stress, secrete inflammatory molecules that increase tissue damage, impair healing, and accelerate disease severity. 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