{"id":41352,"date":"2025-09-01T10:01:49","date_gmt":"2025-09-01T00:01:49","guid":{"rendered":"https:\/\/www.bitemagazine.com.au\/?p=41352"},"modified":"2025-09-03T08:47:45","modified_gmt":"2025-09-02T22:47:45","slug":"hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats","status":"publish","type":"post","link":"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/","title":{"rendered":"Hypoxia leads to reduced dental bone formation during orthodontic tooth movement in rats"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research.jpg\" alt=\"hypoxia dental bone formation \" class=\"wp-image-41353 lazyload\" style=\"width:400px\" data-srcset=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research.jpg 1024w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-300x300.jpg 300w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-150x150.jpg 150w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-768x768.jpg 768w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-420x420.jpg 420w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-840x840.jpg 840w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-600x600.jpg 600w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-696x696.jpg 696w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><noscript><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research.jpg\" alt=\"hypoxia dental bone formation \" class=\"wp-image-41353 lazyload\" style=\"width:400px\" srcset=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research.jpg 1024w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-300x300.jpg 300w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-150x150.jpg 150w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-768x768.jpg 768w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-420x420.jpg 420w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-840x840.jpg 840w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-600x600.jpg 600w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research-696x696.jpg 696w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><figcaption class=\"wp-element-caption\">Credit: Institute of Science Tokyo<\/figcaption><\/figure><\/div>\n\n\n<p>Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report a Japanese team.&nbsp;<\/p>\n\n\n\n<p>Hypoxic conditions resulted in reduced alveolar bone levels after OTM and lower expression of runt-related transcription factor 2 and vascular endothelial growth factor. These findings, observed in a rat model, provide critical insights into the bone remodelling process in OTM under hypoxia.<\/p>\n\n\n\n<p>Orthodontic tooth movement refers to the movement of a tooth due to an externally applied mechanical force. During OTM, the\u00a0periodontal ligament\u00a0(PDL) tissue around the tooth activates biochemical responses to recruit specific bone cells and chemical messenger molecules to aid bone remodelling. While PDL tissues are stretched on the tension side, resulting in bone deposition, orthodontic forces gradually constrict the PDL on the compression side, driving\u00a0bone resorption.<\/p><div class=\"bitem-article-desktop-720x300-in-text\" id=\"bitem-1038652480\"><!-- Bite 720x300 [async] -->\r\n<script type=\"text\/javascript\">if (!window.AdButler){(function(){var s = document.createElement(\"script\"); s.async = true; s.type = \"text\/javascript\";s.src = 'https:\/\/servedby.engagemedia.com.au\/app.js';var n = document.getElementsByTagName(\"script\")[0]; n.parentNode.insertBefore(s, n);}());}<\/script>\r\n<script type=\"text\/javascript\">\r\nvar AdButler = AdButler || {}; AdButler.ads = AdButler.ads || [];\r\nvar abkw = window.abkw || '';\r\nvar plc705185 = window.plc705185 || 0;\r\ndocument.write('<'+'div id=\"placement_705185_'+plc705185+'\"><\\\/'+'div>');\r\nAdButler.ads.push({handler: function(opt){ AdButler.register(165450, 705185, [720,300], 'placement_705185_'+opt.place, opt); }, opt: { place: plc705185++, keywords: abkw, domain: 'servedby.engagemedia.com.au', click:'CLICK_MACRO_PLACEHOLDER' }});\r\n<\/script><\/div>\n\n\n\n<p>Interestingly, recent reports indicate that a hypoxic environment lacking in oxygen supply is commonly observed on the compression side. Studies have demonstrated that oxygen deprivation can significantly modulate the formation of new dental bone. However, the precise mechanism by which&nbsp;hypoxia&nbsp;influences OTM and bone remodelling remains poorly understood.<\/p>\n\n\n\n<p>To address this research gap, researchers at the Institute of Science Tokyo, have conducted a new study using a rat OTM model. Their research is published in&nbsp;<em><a href=\"https:\/\/www.nature.com\/articles\/s41598-025-07949-9\" target=\"_blank\" rel=\"noreferrer noopener\">Scientific Reports<\/a><\/em>.<\/p>\n\n\n\n<p>&#8220;Considering the relationship between hypoxia and OTM, we hypothesised that a hypoxic environment would alter the bone remodeling process,&#8221; study lead Professor Keiji Moriyama said.&nbsp;<\/p>\n\n\n\n<p>&#8220;We utilised a closed-coil spring made of nickel-titanium to cause OTM and applied it between the right maxillary first molar and the maxillary incisors. To investigate OTM under&nbsp;hypoxic conditions, we housed the animals in a controlled-atmosphere chamber with an oxygen level of 10 per cent.&#8221;<\/p>\n\n\n\n<p>The researchers observed that animals from the hypoxia-OTM group had a higher OTM distance. Notably, the alveolar bone levels on the buccal surface in the hypoxia-OTM group were significantly reduced, indicating that hypoxia may upregulate bone resorption via osteoclast activity during OTM.<\/p>\n\n\n\n<p>During histological examination of dental tissue, the scientists identified osteoblast cells that help form new bone, arranged along the alveolar bone on the tension side in OTM groups. However, increased osteoclastic activity was found within the PDL on the compression side.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report a Japanese team.&nbsp; Hypoxic conditions resulted in reduced alveolar bone levels after OTM and lower expression of runt-related transcription factor 2 and vascular endothelial growth factor. These findings, observed in a rat model, provide critical insights into the bone remodelling process [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":41353,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[8],"tags":[24510,25751,70],"class_list":{"0":"post-41352","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-dental_news","8":"tag-dental-bone-and-tissue-regeneration","9":"tag-hypoxia","10":"tag-orthodontics"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.9 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hypoxia leads to reduced dental bone formation during orthodontic tooth movement in rats - Bite Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hypoxia leads to reduced dental bone formation during orthodontic tooth movement in rats\" \/>\n<meta property=\"og:description\" content=\"Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report a Japanese team.&nbsp; Hypoxic conditions resulted in reduced alveolar bone levels after OTM and lower expression of runt-related transcription factor 2 and vascular endothelial growth factor. These findings, observed in a rat model, provide critical insights into the bone remodelling process [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/\" \/>\n<meta property=\"og:site_name\" content=\"Bite Magazine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Bite.Mag\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-01T00:01:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-02T22:47:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Editor\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Editor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/\"},\"author\":{\"name\":\"Editor\",\"@id\":\"https:\/\/www.bitemagazine.com.au\/#\/schema\/person\/d9a0da9738e8b22c86465898e79cff17\"},\"headline\":\"Hypoxia leads to reduced dental bone formation during orthodontic tooth movement in rats\",\"datePublished\":\"2025-09-01T00:01:49+00:00\",\"dateModified\":\"2025-09-02T22:47:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/\"},\"wordCount\":382,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2025\/09\/japanese-research.jpg\",\"keywords\":[\"dental bone and tissue regeneration\",\"hypoxia\",\"orthodontics\"],\"articleSection\":[\"Dental News\"],\"inLanguage\":\"en-AU\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/\",\"url\":\"https:\/\/www.bitemagazine.com.au\/hypoxia-leads-to-reduced-dental-bone-formation-during-orthodontic-tooth-movement-in-rats\/\",\"name\":\"Hypoxia leads to reduced dental bone formation during orthodontic tooth movement in rats - 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