{"id":6956,"date":"2015-10-08T15:24:40","date_gmt":"2015-10-08T04:24:40","guid":{"rendered":"https:\/\/www.bitemagazine.com.au\/?p=6956"},"modified":"2016-01-13T12:31:32","modified_gmt":"2016-01-13T01:31:32","slug":"oligodontia-research-breakthrough","status":"publish","type":"post","link":"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/","title":{"rendered":"Oligodontia research breakthrough"},"content":{"rendered":"<h4><a href=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-6957 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg\" alt=\"oligodontia\" width=\"1024\" height=\"421\" data-srcset=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg 1024w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-300x123.jpg 300w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-768x316.jpg 768w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-696x286.jpg 696w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-1022x420.jpg 1022w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-150x62.jpg 150w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-310x127.jpg 310w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><noscript><img decoding=\"async\" class=\"aligncenter size-full wp-image-6957 lazyload\" src=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg\" alt=\"oligodontia\" width=\"1024\" height=\"421\" srcset=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg 1024w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-300x123.jpg 300w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-768x316.jpg 768w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-696x286.jpg 696w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-1022x420.jpg 1022w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-150x62.jpg 150w, https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel-310x127.jpg 310w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/a>Researchers at the <a href=\"http:\/\/www.umcutrecht.nl\/en\/Research\" target=\"_blank\">University Medical Center Utrecht<\/a> [UMC], the Netherlands, have discovered a gene, described as LPR6, that may cause oligodontia, the absence of six or more teeth. With the team\u2019s findings published in the recent edition of The American Journal of Human Genetics, the discovery makes it possible to diagnose patients more effectively and provide them with better information and tailored treatment.<\/h4>\n<p>While local studies are limited, oligodontia affects 14 out of every 10,000 people in Europe, and is found to be the result of genetic mutations. While there are two types of the condition \u2013 oligodontia as part of a syndrome and oligodontie as an isolated condition \u2013 possible causes include viral disease during pregnancy, genetic predisposition, metabolic imbalances, developmental abnormalities and environmental factors. It has been known to lead to speech difficulties, low self-esteem and complicated and oftentimes uncomfortable treatments.<\/p>\n<p>The UMC study involved genetic testing in 20 patients with nonsyndromic oligodontia using whole exome sequencing, which identifies the protein coding regions of the human genome. The research revealed not only that the condition is caused by a mutation in the LPR6 gene, but also that patients indicate a 50 per cent chance of passing the mutation on to their children. \u201cIn these patients, the gene is primarily associated with the absence of teeth and, in principle, not with other serious conditions,\u201d wrote Dr Marie-Jose van den Boogaard, a clinical geneticist at UMC involved in the study.<\/p>\n<p>\u201cMost patients want to know the cause. Why does it develop? Will my children get it as well? And what is the risk of this happening? This new research provides better insight into the biology of tooth development. The LPR6 gene is now included in the DNA diagnostics of oligodontia, enabling us to give patients a better diagnosis, and to provide better information and to develop customised treatment.\u201d<\/p><div class=\"bitem-article-desktop-720x300-in-text\" id=\"bitem-987676307\"><!-- Bite 720x300 [async] -->\r\n<script type=\"text\/javascript\">if (!window.AdButler){(function(){var s = document.createElement(\"script\"); s.async = true; s.type = \"text\/javascript\";s.src = 'https:\/\/servedby.engagemedia.com.au\/app.js';var n = document.getElementsByTagName(\"script\")[0]; n.parentNode.insertBefore(s, n);}());}<\/script>\r\n<script type=\"text\/javascript\">\r\nvar AdButler = AdButler || {}; AdButler.ads = AdButler.ads || [];\r\nvar abkw = window.abkw || '';\r\nvar plc705185 = window.plc705185 || 0;\r\ndocument.write('<'+'div id=\"placement_705185_'+plc705185+'\"><\\\/'+'div>');\r\nAdButler.ads.push({handler: function(opt){ AdButler.register(165450, 705185, [720,300], 'placement_705185_'+opt.place, opt); }, opt: { place: plc705185++, keywords: abkw, domain: 'servedby.engagemedia.com.au', click:'CLICK_MACRO_PLACEHOLDER' }});\r\n<\/script><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University Medical Center Utrecht [UMC], the Netherlands, have discovered a gene, described as LPR6, that may cause oligodontia, the absence of six or more teeth. With the team\u2019s findings published in the recent edition of The American Journal of Human Genetics, the discovery makes it possible to diagnose patients more effectively and [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":6957,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[8],"tags":[1986],"class_list":{"0":"post-6956","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-dental_news","8":"tag-oligodontia"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.9 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Oligodontia research breakthrough - Bite Magazine<\/title>\n<meta name=\"description\" content=\"Researchers at the University Medical Centre Utrecht have discovered a gene, LPR6, that may cause oligodontia, the absence of six or more teeth.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oligodontia research breakthrough\" \/>\n<meta property=\"og:description\" content=\"Researchers at the University Medical Centre Utrecht have discovered a gene, LPR6, that may cause oligodontia, the absence of six or more teeth.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/\" \/>\n<meta property=\"og:site_name\" content=\"Bite Magazine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Bite.Mag\" \/>\n<meta property=\"article:published_time\" content=\"2015-10-08T04:24:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2016-01-13T01:31:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"421\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Editor\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Editor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/\"},\"author\":{\"name\":\"Editor\",\"@id\":\"https:\/\/www.bitemagazine.com.au\/#\/schema\/person\/d9a0da9738e8b22c86465898e79cff17\"},\"headline\":\"Oligodontia research breakthrough\",\"datePublished\":\"2015-10-08T04:24:40+00:00\",\"dateModified\":\"2016-01-13T01:31:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/\"},\"wordCount\":306,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.bitemagazine.com.au\/wp-content\/uploads\/2015\/10\/1.-Oligodontie-beugel.jpg\",\"keywords\":[\"Oligodontia\"],\"articleSection\":[\"Dental News\"],\"inLanguage\":\"en-AU\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/\",\"url\":\"https:\/\/www.bitemagazine.com.au\/oligodontia-research-breakthrough\/\",\"name\":\"Oligodontia research breakthrough - 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